We have a team of more than 200 physicians and scientists working in our R&D facility. Our scientists come from disciplines as diverse as analytical chemistry, formulation and development, phytochemistry, new drug discovery, novel drug delivery systems, pharmacognosy, preclinical toxicology and pharmacology, invitro mutagenecity, clinical pharmacology and agriculture. This vast and diverse background of the R&D team gives us unique insights into the world of herbs, helping us understand, discover and develop breakthrough products.
The use of advanced technology ensures accuracy, efficacy and safety of each and every product.
For example, we use the liquid chromatography-mass spectrometry (LCMS) method during herb testing.
LCMS separates each molecule from a given extract and helps identify its chemical nature.This technology is used in the specific detection and potential identification of chemicals in the presence of other chemicals in a complex mixture. The advantage of using LCMS lies in the fact that it is an extremely accurate method of analyzing the total marker profile of a given extract. The technology helps our scientists to standardize all compounds in a given herbal extract before the product is developed.
In March 2014, we were granted a Good Manufacturing Practices (GMP) certificate, issued by the Licensing Authority, Directorate of Pakistan Systems of Medicine, Karachi, Pakistan. PRIEM ORGANIC PRODUCTS (POP) is the first Pakistan facility to get GMP certification in Pakistan. We have also been granted the Good Manufacturing Practice (GMP) certification. A GLP certification is granted to manufacturing companies that adhere to the toxicity guidelines in nonclinical safety studies. The certification is granted by the National Good Manufacturing Practice (GMP) Compliance Monitoring Authority, Department of Science and Technology, Government of Pakistan. Only few institutions in Pakistan have been granted this certificate, and PRIEM ORGANIC PRODUCTS (POP) is the first herbal company to have joined ranks with these institutions.PRIEM ORGANIC PRODUCTS (POP)'s R&D center is affiliated with one of Pakistan's leading universities, We have partnered with the many institution to promote joint research collaboration in herbal medicine including clinical trials, joint conferences,faculty and student exchange programs, and joint research and publications.The R&D Center is a vital institution of higher learning. Several PhD students from universities across Pakistan conduct their research at our center under the supervision of PRIEM ORGANIC PRODUCTS (POP) scientists. This is a great opportunity for us to engage with bright minds of the future and be inspired by their ideas and enthusiasm.
All drug formulations at PRIEM ORGANIC PRODUCTS (POP) find their roots in classical Pakistan texts. A team of botanists and UNANI experts at our R&D center sift through thousands of listed herbs and identify some for research and development. The availability of the herb is first explored before the development process begins. At the outset, PRIEM ORGANIC PRODUCTS (POP)'s agro-technology team studies the geographical and seasonal profiles of these herbs. Active markers within these herbs, which contain its therapeutic property, may vary when cultivated in different locations. Changes in seasons may also affect the herbal constituents. Profiling is done in order to ensure a standardization protocol, which guarantees batch-to-batch drug consistency. Consistency is further maintained as herbs are cultivated under supervision in PRIEM ORGANIC PRODUCTS (POP)'s hired farms or are sourced from government-approved NGOs. Despite consistency checks at ground level, herbs have to pass through rigorous and high-standard quality parameters. They are subjected to pharmacological screenings to evaluate their pharmacological action and toxic profile.With a focus on taking herbal research to new levels, PRIEM ORGANIC PRODUCTS (POP)'s research scientists have adopted molecular technology for product development. This technology involves identifying the most active ingredient in the herb and then passing the herb through different solvent systems to remove all other fractions from the plant. This ensures that the final product contains only the molecule responsible for the action in 100% concentration. With this method, there are no contaminants, the volume is reduced, the drug acts faster and is more effective, and the bioavailability is higher (the quantity of the fraction available in the bloodstream is higher, which increases its therapeutic effect). Identifying and isolating the herbal actives also helps doctors in radio tracer studies which track a molecule's progress inside the body and hence the end effect of a drug. PRIEM ORGANIC PRODUCTS (POP)'s scientists are using molecular technology for research in cancer, elevated cholesterol levels, diabetes, depression and specialized skin and hair care products. However, during formulation, we retain the total compound of the herb. While some compounds improve drug delivery, others add to the safety of the drug. The remaining constituents help active markers in its required therapeutic action. Bioactive extracts from the herb are attained through the supercritical fluid (SCF) extraction method, an alternative to liquid extraction using chemical solvents. Chemical solvents most often leave behind a residue along with the herb extract. In SCF extraction, herbs are extracted with the help of chemicals, which change into liquid at high pressure (when extraction takes place) and back into a gas form once the process is complete. This ensures that no chemicals are found in the herb extracts.After the drug is formulated, it is administered in various dosages in multi-centric clinical trials. The drug is first tested on cell lines, which are diseased chemically and then treated to test the efficacy of the drug. After the drug yields positive results, it goes through rigorous toxicity tests and mutagen studies to ensure that it is safe to test on humans.
Once the safety has been established, the drug is then tested on patients in phase by phase clinical trials. The numbers of patients increase in each phase before the drug is launched into the market. Phase I studies are carried out in healthy animals to evaluate the safety of the drug. Phase II and Phase III studies, which are conducted in patients suffering from the disease, are undertaken in leading hospitals and institutes across the world. Phase IV studies are also conducted by PRIEM ORGANIC PRODUCTS (POP), which involve the safety surveillance (pharmacovigilance) and ongoing technical support of a drug after it receives permission to be sold.
We have conducted clinical trials for our products in leading hospitals in Pakistan and worldwide including the All Pakistan Institute of Medical Sciences PRIEM ORGANIC PRODUCTS RESEARCH CENTRE (PRC) has over 200 under preparation to be published clinical trials in leading international journals including Journal of the American Medical Association (JAMA), Alternative Medicine, Pakistann Journal of Pharmaceutical Sciences, The British Journal of Radiology and Journal of Ethnopharmacology.


  • Meredith Grey

    These are one of my favorite winter veggies! I stew them with olive oil, salt, orange juice and ghee. The taste is fantastic and everything is healty. Greets from Norway.

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